Echoes Of Pain


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Regrettably the precise contribution of spinal mechanisms in predicting the strength of placebo analgesia is unknown. Here, we show that expectations regarding pain radically change the strength of spinal nociceptive responses in humans. We found that contrary to expectations of analgesia, expectations of hyperalgesia completely blocked the analgesic effects of descending inhibition on spinal nociceptive reflexes.

Echoes of Abraham - Pain and Pilgrimage in Jerusalem

Somatosensory-evoked brain potentials and pain ratings further confirmed changes in spino-thalamo-cortical responses consistent with expectations and with changes in the spinal response. These findings provide direct evidence that the modulation of pain by expectations is mediated by endogenous pain modulatory systems affecting nociceptive signal processing at the earliest stage of the central nervous system.

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Echoes Of Pain Echoes Of Pain
Echoes Of Pain Echoes Of Pain
Echoes Of Pain Echoes Of Pain
Echoes Of Pain Echoes Of Pain
Echoes Of Pain Echoes Of Pain

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